Nurse Mpho Matloane  prepares a syringe filled with the drug Lenacapavir which he prepares to administer to Kegoratile Aphane (left) at the Phedisong clinic in Ga-Rankuwa, north-west of Pretoria, on Dec. 2, 2025.

A new twice-yearly HIV prevention injection could transform South Africa's fight against the epidemic — but U.S. aid cuts and limited doses threaten to slow its impact.

(Image credit: Ihsaan Haffe)