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NRL premiership winning halfback partners Nathan Cleary and Jarome Luai will lock horns as Wests Tigers host the Penrith Panthers.
Later, Cronulla Sutherland Sharks host a St George Illawarra Dragons team desperate to build on their first win of the NRL season last week.
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Heamasi Makasini was at risk of missing out in the centres after suffering an AC joint injury, but he's pulled up well and will take his spot in the 4 jersey.
Mavrik Geyer steps into the second row after Sione Fainu was ruled with concussion, with Charlie Murray getting his first start of the year at lock.
All the big names are back from their Origin rest last week, meaning Nathan Cleary will get to front up against good mate and premiership winning half Jarome Luai.
Isaah Yeo and Brian To'o also return which puts Jack Cogger, Liam Henry and Izack Tago on the pine.
Benji Marshall will encourage straight-shooting prop Terrell May to keep speaking his mind after the Wests Tigers star made several headline-grabbing claims about his treatment in the NRL.
Marshall said the Tigers admired May's honesty after his star front-rower appeared on the Unscripted podcast with ex-NRL winger Josh Mansour.
May, who was mysteriously cut by the Sydney Roosters in 2024, remains unsure why he is unable to get a look-in by the NSW State of Origin set-up despite becoming one of the NRL's leading props since joining the Tigers.
The 27-year-old claimed he and his brother Taylan had been blacklisted by the NRL's social media team — a suggestion League Central has denied — and said his loyalty was to Marshall and not to the Tigers.
"Loyalty is a two-way street. It means everything, it's what you want your players to be," Marshall said.
But the Tigers front-rower also accused Matt Cameron of referring to him as a "gangster" when May met with the Penrith chief executive about signing with the Panthers in 2022, adding a touch of spice to today's game.
"As a game, we want players to be honest and express themselves and be who they are, and then when they are who they are and tell the truth, we don't like it," Marshall said.
"One thing that I love about Terrell is and what we want [is for] him to be himself and express himself.
"He tells the truth and sometimes people don't like that, but that's who Terrell is and we love that part of him.
"But what he says is, that's up to him, and I want him to say how he feels."
The Tigers are without Alex Twal after he picked up a knee injury in last week's win over Canterbury that arrested a nosedive in form from Marshall's side, who boast a 6-5 record in 2026.
"Winning softens your mindset and it has the ability to make you think you're going better than you are," Marshall said.
"We had a three-game losing streak where we let in almost 40 points a game that I wasn't happy with.